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19-147 | U0126

1 mg  
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      Replacement Information

      Key Specifications Table

      Uni Prot Number
      Q02750, P36507
      Catalogue Number19-147
      Brand Family Upstate
      Trade Name
      • Upstate
      Product Information
      ApplicationU0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
      Gene Symbol
      • MAP2K1
      • MAPKK1
      • PRKMK1
      • MEK1
      • MKK1
      Protein TargetMAPKK 1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
      SIZE: 393 amino acids; 43439 Da
      SUBUNIT: Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.
      PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. & Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
      DISEASE: SwissProt: Q02750 # Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
      SIMILARITY: SwissProt: Q02750 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      U0126 - 2388946 2388946
      U0126 - 0611046576 0611046576
      U0126 - 19203 19203
      U0126 - 2033908 2033908
      U0126 - 21096 21096
      U0126 - 2196174 2196174
      U0126 - 2200941 2200941
      U0126 - 2276329 2276329
      U0126 - 23190 23190
      U0126 - 2533236 2533236
      U0126 - 27449 27449
      U0126 - 29529 29529
      U0126 - DAM1467565 DAM1467565
      U0126 - DAM1567801 DAM1567801
      U0126 - DAM1718103 DAM1718103
      U0126 -2492828 2492828
      U0126 -2660614 2660614
      U0126 -2677205 2677205
      U0126 -2700877 2700877
      U0126 -2816728 2816728


      Reference overviewApplicationPub Med ID
      Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery.
      Okano J, and Rustgi, A K
      J. Biol. Chem., 276: 19555-64 (2001) 2001

      Show Abstract
      Kinase Assay11278851 11278851
      Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy.
      DeSilva, D R, et al.
      J. Immunol., 160: 4175-81 (1998) 1998

      Show Abstract
      9574517 9574517
      Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
      Favata, M F, et al.
      J. Biol. Chem., 273: 18623-32 (1998) 1998

      Show Abstract
      9660836 9660836
      Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.
      Scherle, P A, et al.
      J. Immunol., 161: 5681-6 (1998) 1998

      Show Abstract
      9820549 9820549