657021 Tyrosine Kinase Inhibitor Set II - Calbiochem

657021
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      657021-1SET
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 1 set
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewContains 20 mg of Genistein (Cat. No. 345834), 1 mg of PP2 (Cat. No. 529573), 5 mg of AG 490 (Cat. No. 658401), 5 mg of AG 1296 (Cat. No. 658551), and 5 mg of AG 1478 (Cat. No. 658552). Supplied with an informational insert.
          Catalogue Number657021
          Brand Family Calbiochem®
          Application Data













          References
          ReferencesHanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
          Meydan, N., et al. 1996. Nature 379, 645.
          Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Product Information
          ATP CompetitiveY
          FormSolid
          Applications
          Biological Information
          Primary TargetEGFR
          Secondary targetPKC, Src family of protein tyrosine kinases, JAK2
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tyrosine Kinase Inhibitor Set II - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Tyrosine Kinase Inhibitor Set II - Calbiochem Certificates of Analysis

          TitleLot Number
          657021

          References

          Reference overview
          Hanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
          Meydan, N., et al. 1996. Nature 379, 645.
          Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-September-2008 RFH
          Application Data













          DescriptionProtein tyrosine phosphorylation is a key element in several membrane signal transduction systems. There are two general classes of tyrosine kinases: the receptor tyrosine kinases and the receptor-associated tyrosine kinases. The receptor tyrosine kinases possess an extracellular ligand binding domain and an intracellular catalytic domain with intrinsic tyrosine kinase activity. The receptor-associated tyrosine kinases transmit signals from the membrane by interacting with the cytoplasmic domain of membrane proteins.

          The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.

          The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          SolubilityConcentrated solutions of ≥1 mg/ml should be prepared in anhydrous DMSO.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesHanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
          Meydan, N., et al. 1996. Nature 379, 645.
          Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.