654380 Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

654380
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₉H₆₄N₄O₁₆ 11089-65-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      654380-10MG
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          Glass bottle 10 mg
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          654380-50MG
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              Alu drum 50 mg
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              Description
              OverviewA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
              Catalogue Number654380
              Brand Family Calbiochem®
              References
              ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
              Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
              Product Information
              CAS number11089-65-9
              FormWhite to off-white solid
              Hill FormulaC₃₉H₆₄N₄O₁₆
              Chemical formulaC₃₉H₆₄N₄O₁₆
              ReconstitutionAqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetN-linked glycosylation
              Secondary targetthrombin-induced Ca2+ mobilization in cells
              Purity≥98% by HPLC (A+B+C+D)
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSYO7980200
              Safety Information
              R PhraseR: 26/27/28-60-61

              Very toxic by inhalation, in contact with skin and if swallowed.
              May impair fertility.
              May cause harm to the unborn child.
              S PhraseS: 22-36/37/39-45

              Do not breathe dust.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Certificates of Analysis

              TitleLot Number
              654380

              References

              Reference overview
              Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
              Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.

              Brochure

              Title
              Antibiotics Profiler

              Citations

              Title
            • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
            • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
            • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-September-2007 RFH
              DescriptionA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells.
              FormWhite to off-white solid
              CAS number11089-65-9
              RTECSYO7980200
              Chemical formulaC₃₉H₆₄N₄O₁₆
              Structure formulaStructure formula
              Purity≥98% by HPLC (A+B+C+D)
              SolubilityDMSO (10 mg/ml), DMF, or Pyridine. Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.
              Storage +15°C to +30°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Merck USA index14, 9819
              ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
              Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
              Citation
            • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
            • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
            • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.