506300 | TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem

506300
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₄ 38183-03-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06300.0001
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          Glass bottle 100 mg
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          Description
          OverviewA cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
          Catalogue Number506300
          Brand Family Calbiochem®
          Synonyms7,8-DHF
          References
          ReferencesRen, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
          Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
          Jang, S., et al. 2010. PNAS 107, 2687.
          Product Information
          CAS number38183-03-8
          FormYellow powder
          Hill FormulaC₁₅H₁₀O₄
          Chemical formulaC₁₅H₁₀O₄
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTrkB
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Ren, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
          Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
          Jang, S., et al. 2010. PNAS 107, 2687.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-November-2013 JSW
          Synonyms7,8-DHF
          DescriptionA cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number38183-03-8
          Chemical formulaC₁₅H₁₀O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesRen, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
          Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
          Jang, S., et al. 2010. PNAS 107, 2687.