647925 Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

647925
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₂N₂O₃ 58880-19-6

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      647925-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A. 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
          Catalogue Number647925
          Brand Family Calbiochem®
          Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
          References
          ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
          Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
          Product Information
          CAS number58880-19-6
          ATP CompetitiveN
          FormOff-white lyophilized solid
          Hill FormulaC₁₇H₂₂N₂O₃
          Chemical formulaC₁₇H₂₂N₂O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationTrichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).
          Biological Information
          Primary Targethistone deactylase
          Primary Target IC<sub>50</sub>73 nM inhibiting IL-2 gene expressionin Jurkat cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMI5215000
          Safety Information
          R PhraseR: 20/21/22-36/37/38-43

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          647925

          References

          Reference overview
          Furumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
          Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.

          Brochure

          Title
          Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)

          Technical Info

          Title
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)

          Citations

          Title
        • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2016 JSW
          Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
          DescriptionA potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A.
          FormOff-white lyophilized solid
          CAS number58880-19-6
          RTECSMI5215000
          Chemical formulaC₁₇H₂₂N₂O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (20 mg/ml), ethanol (1 mg/ml), or methanol
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
          Toxicity Harmful
          ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
          Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
          Citation
        • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.