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616400 | Tranilast - CAS 53902-12-8 - Calbiochem

616400
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₇NO₅ 53902-12-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      616400-10MG
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          Glass bottle 10 mg
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          Description
          OverviewAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
          Catalogue Number616400
          Brand Family Calbiochem®
          SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
          References
          ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
          Isaji, M., et al. 1998. Life Sci. 63, PL71.
          Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
          Product Information
          CAS number53902-12-8
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₁₈H₁₇NO₅
          Chemical formulaC₁₈H₁₇NO₅
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetVEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDG8731000
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          616400

          References

          Reference overview
          Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
          Isaji, M., et al. 1998. Life Sci. 63, PL71.
          Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
          DescriptionAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number53902-12-8
          RTECSDG8731000
          Chemical formulaC₁₈H₁₇NO₅
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Toxicity Harmful
          Merck USA index14, 9570
          ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
          Isaji, M., et al. 1998. Life Sci. 63, PL71.
          Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.