612200 Tissue Plasminogen Activator, Human

612200
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      612200-100UG
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          Plastic ampoule 100 μg
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          612200-1MG
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              Glass bottle 1 mg
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              Description
              OverviewNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.
              Catalogue Number612200
              Brand Family Calbiochem®
              SynonymstPA
              References
              ReferencesKim, Y.H., et al. 1999. Science 284, 647.
              Tsirka, S.E., et al. 1995. Nature 377, 340.
              Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
              Product Information
              FormLyophilized
              FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
              Applications
              Biological Information
              Purity≥95% by SDS-PAGE
              SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
              Specific Activity≥300 KU/mg protein
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Blue Ice Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Tissue Plasminogen Activator, Human SDS

              Title

              Safety Data Sheet (SDS) 

              Tissue Plasminogen Activator, Human Certificates of Analysis

              TitleLot Number
              612200

              References

              Reference overview
              Kim, Y.H., et al. 1999. Science 284, 647.
              Tsirka, S.E., et al. 1995. Nature 377, 340.
              Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision17-May-2011 JSW
              SynonymstPA
              DescriptionNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acid residues. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration. Dihydropyridine Ca2+ antagonist may increase levels of tPA.
              FormLyophilized
              FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
              SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
              Purity≥95% by SDS-PAGE
              Specific activity≥300 KU/mg protein
              SolubilityReconstitute with diH₂O to a final concentration of 1 mg/ml (e.g., 100 µg should be reconstituted in 100 µl).
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesKim, Y.H., et al. 1999. Science 284, 647.
              Tsirka, S.E., et al. 1995. Nature 377, 340.
              Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.