A part of MilliporeSigma

612085 | Tie2 Kinase Inhibitor - CAS 948557-43-5 - Calbiochem

612085
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₁N₃O₂S 948557-43-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      612085-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable pyridinylimidazole compound that acts as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2 (IC50 = 250 nM) with ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. Shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.
          Catalogue Number612085
          Brand Family Calbiochem®
          Synonyms4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
          References
          ReferencesSemones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.
          Product Information
          CAS number948557-43-5
          FormOrange-tan solid
          Hill FormulaC₂₆H₂₁N₃O₂S
          Chemical formulaC₂₆H₂₁N₃O₂S
          Structure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          612085

          References

          Reference overview
          Semones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-May-2011 RFH
          Synonyms4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
          DescriptionA cell-permeable pyridinylimidazole compound that acts as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2 (IC50 = 250 nM) with ~200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. Shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.
          FormOrange-tan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number948557-43-5
          Chemical formulaC₂₆H₂₁N₃O₂S
          Structure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSemones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.