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506236 | Tiagabine Hydrochloride - CAS 145821-59-6 - Calbiochem

506236
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₅NO₂S₂·HCl 145821-59-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06236.0001
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          Glass bottle 10 mg
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          Description
          OverviewA potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
          Catalogue Number506236
          Brand Family Calbiochem®
          SynonymsGABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
          References
          ReferencesLaughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
          Hu, Q., et al. 1997. Brain Res. 753,260.
          Suzdak, P., et al., 1995. Epilepsia. 36, 612.
          Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.
          Product Information
          CAS number145821-59-6
          FormOff-white solid
          Hill FormulaC₂₀H₂₅NO₂S₂·HCl
          Chemical formulaC₂₀H₂₅NO₂S₂·HCl
          Structure formula Image
          Applications
          Biological Information
          Primary TargetGAT-1
          Primary Target IC<sub>50</sub>67 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
          Hu, Q., et al. 1997. Brain Res. 753,260.
          Suzdak, P., et al., 1995. Epilepsia. 36, 612.
          Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          SynonymsGABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
          DescriptionA potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
          FormOff-white solid
          CAS number145821-59-6
          Chemical formulaC₂₀H₂₅NO₂S₂·HCl
          Structure formula
          Purity≥98% by HPLC
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLaughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
          Hu, Q., et al. 1997. Brain Res. 753,260.
          Suzdak, P., et al., 1995. Epilepsia. 36, 612.
          Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.