609315 Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem

609315
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₀F₃N₅O₄ 251310-57-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      609315-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRα with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor α (RARα) activity.
          Catalogue Number609315
          Brand Family Calbiochem®
          SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
          References
          ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
          Product Information
          CAS number251310-57-3
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₁H₂₀F₃N₅O₄
          Chemical formulaC₂₁H₂₀F₃N₅O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetThyroid Hormone Receptor
          Primary Target IC<sub>50</sub>1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          609315

          References

          Reference overview
          Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-December-2015 JSW
          SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
          DescriptionA cell-permeable, selective, high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Reported to block T3-L-triiodothyronine)-mediated interaction of TRα with nuclear receptor coactivator (NRC) and prevent stimulation of gene expression. Exhibits no antagonistic effects on retinoic acid receptor α (RARα) activity.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number251310-57-3
          Chemical formulaC₂₁H₂₀F₃N₅O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.