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58346 | Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem

58346
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₄N₂O₈ 64-75-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      58346-10GM
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          Glass bottle 10 gm
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          58346-25GM
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              Glass bottle 25 gm
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              58346-50GM
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                  Glass bottle 50 gm
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                  Description
                  OverviewBroad-based antibiotic agent that blocks protein synthesis by inhibiting binding of aminoacyl tRNA to the A-site of ribosomes. Induces cold shock-response and enhances P450 expression in bacteria.
                  Catalogue Number58346
                  Brand Family Calbiochem®
                  References
                  ReferencesKusano, K., et al. 1999. Arch. Biochem. Biophys. 367, 129.
                  Lech, K. and Brent, R. 1995. In Current Protocols in Molecular Biology, Vol. 1 (Ausubel, F.M., et al. eds.) John Wiley & Sons, New York Unit 1.4.
                  Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York, p. 1.6, A.6.
                  Chopra, I. and Howe, T.G.B. 1978. Microbiol. Rev. 42, 707.
                  Product Information
                  CAS number64-75-5
                  Activity≥900 µg/mg
                  FormYellow crystalline solid
                  Hill FormulaC₂₂H₂₄N₂O₈
                  Chemical formulaC₂₂H₂₄N₂O₈
                  Structure formula Image
                  Applications
                  Biological Information
                  Primary Targetbinding of aminoacyl tRNA to the A-site of ribosomes
                  Physicochemical Information
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSQI9100000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage +15°C to +30°C
                  Protect from Light Protect from light
                  Protect from Moisture Protect from moisture
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for 1 month at -20°C. Agar plates are stable for 2 weeks at 4°C. Autoclaved media should be cooled to ≤55°C before adding tetracycline.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  58346

                  References

                  Reference overview
                  Kusano, K., et al. 1999. Arch. Biochem. Biophys. 367, 129.
                  Lech, K. and Brent, R. 1995. In Current Protocols in Molecular Biology, Vol. 1 (Ausubel, F.M., et al. eds.) John Wiley & Sons, New York Unit 1.4.
                  Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York, p. 1.6, A.6.
                  Chopra, I. and Howe, T.G.B. 1978. Microbiol. Rev. 42, 707.

                  Brochure

                  Title
                  Antibiotics Profiler
                  BLEOCIN Technical Bulletin
                  Competent Cell Brochure
                  Drugs for Selection of Genetic Markers Technical Bulletin
                  Overnight Express Autoinduction Systems

                  Technical Info

                  Title
                  EMD Millipore Regulated Product Information

                  Citations

                  Title
                • Thomas S. Lendvay, et al. (2007) Compensatory paracrine mechanisms that define the urothelial response to injury in partial bladder outlet obstruction. American Journal of Physiology: Renal 293, F1147-F1156.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision13-September-2007 JSW
                  DescriptionAn antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing binding of aminoacyl tRNA to the A-site and blocking translocation. Used commonly for selection of the bacterial tetr gene whose product, a 399-amino acid membrane-associated protein, functions in active export of the drug from the cell.
                  FormYellow crystalline solid
                  CAS number64-75-5
                  RTECSQI9100000
                  Chemical formulaC₂₂H₂₄N₂O₈
                  Structure formula
                  Activity≥900 µg/mg
                  SolubilityEthanol (5 mg/ml) or H₂O (20 mg/ml)
                  Storage +15°C to +30°C
                  Protect from light
                  Protect from moisture
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for 1 month at -20°C. Agar plates are stable for 2 weeks at 4°C. Autoclaved media should be cooled to ≤55°C before adding tetracycline.
                  Toxicity Standard Handling
                  Merck USA index14, 9196
                  ReferencesKusano, K., et al. 1999. Arch. Biochem. Biophys. 367, 129.
                  Lech, K. and Brent, R. 1995. In Current Protocols in Molecular Biology, Vol. 1 (Ausubel, F.M., et al. eds.) John Wiley & Sons, New York Unit 1.4.
                  Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York, p. 1.6, A.6.
                  Chopra, I. and Howe, T.G.B. 1978. Microbiol. Rev. 42, 707.
                  Citation
                • Thomas S. Lendvay, et al. (2007) Compensatory paracrine mechanisms that define the urothelial response to injury in partial bladder outlet obstruction. American Journal of Physiology: Renal 293, F1147-F1156.