654256 TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

654256
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O 1049741-03-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      654256-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
          Catalogue Number654256
          Brand Family Calbiochem®
          Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor
          References
          ReferencesHe, M.M., et al. 2005. Science 310, 1022.
          Product Information
          CAS number1049741-03-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
          Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTNF-α
          Primary Target IC<sub>50</sub>22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          654256

          References

          Reference overview
          He, M.M., et al. 2005. Science 310, 1022.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor
          DescriptionA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1049741-03-8
          Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHe, M.M., et al. 2005. Science 310, 1022.