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CC1062 | TIMP-1, recombinant, active human

CC1062
5 µg  5 μg/vial
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      Overview

      Replacement Information
      Description
      Catalogue NumberCC1062
      ReplacesCC1063
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionTIMP-1, recombinant, active human
      OverviewHuman TIMP-1, isolated from CHO cells transfected with human TIMP-1 cDNA. A single band at 29kDa is noted by SDS-PAGE.
      References
      Product Information
      PresentationPurified protein in 10 mM Sodium Phosphate, pH 7.3, 0.15M NaCl.
      Applications
      Key Applications
      • Inhibits Activity/Function
      Biological Information
      Concentrationvaries by lot
      Specific ActivityBIOLOGICAL ACTIVITY: <br /><br />IC50=1.38 x 10E-9M (versus 6.7 x 10E-9 M MMP-1). [Nagai, Y, (1984) Jpn. Jp. Inflam. 4:123-130]
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
      Gene Symbol
      • TIMP1
      • TIMP
      • FLJ90373
      • CLGI
      • EPA
      • EPO
      • TIMP-1
      • HCI
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
      SIZE: 207 amino acids; 23171 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
      SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      • Manufactured by Daiichi Fine Chemical Co., Ltd
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size5 µg
      Material Package5 μg/vial
      Transport Information
      Supplemental Information
      Specifications