616453 TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

616453
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₁N₃O₂ • HCl 356559-13-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      616453-2MG
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          Plastic ampoule 2 mg
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          Description
          OverviewA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
          Catalogue Number616453
          Brand Family Calbiochem®
          SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
          References
          ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
          DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.
          Product Information
          CAS number356559-13-2
          ATP CompetitiveY
          FormLight yellow solid
          Hill FormulaC₂₀H₂₁N₃O₂ • HCl
          Chemical formulaC₂₀H₂₁N₃O₂ • HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetActivin receptor-like kinase 4, 5, 7
          Primary Target IC<sub>50</sub>129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          616453

          References

          Reference overview
          Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
          DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.

          Brochure

          Title
          TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis (EMD)

          Technical Info

          Title
          TGF-β Signaling: Dual Role in Tumor Suppression and Oncogenesis
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2008 RFH
          SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
          DescriptionA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number356559-13-2
          Chemical formulaC₂₀H₂₁N₃O₂ • HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (20 mg/ml) or H₂O (3 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
          DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.