574662 Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem

574662
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₉BrN₄O₃ 781661-94-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      574662-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
          Catalogue Number574662
          Brand Family Calbiochem®
          SynonymsSurvivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
          References
          ReferencesNakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
          Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
          Nakahara, T., et al. 2007, Cancer Res. 67, 8014.
          Product Information
          CAS number781661-94-7
          FormYellow solid
          Hill FormulaC₂₀H₁₉BrN₄O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target Interleukin enhancer-binding factor 3 (ILF3/NF110)
          Primary Target IC<sub>50</sub>540nM
          Secondary targetUnknown
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          574662

          References

          Reference overview
          Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
          Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
          Nakahara, T., et al. 2007, Cancer Res. 67, 8014.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-March-2017 JSW
          SynonymsSurvivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
          DescriptionA cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number781661-94-7
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesNakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
          Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
          Nakahara, T., et al. 2007, Cancer Res. 67, 8014.