05-23-0600 | Substance P - CAS 33507-63-0 - Calbiochem

05-23-0600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆₃H₉₈N₁₈O₁₃S 33507-63-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      05-23-0600-1MG
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          Plastic ampoule 1 mg
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          05-23-0600-25MG
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              Plastic ampoule 25 mg
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              05-23-0600-5MG
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                  Plastic ampoule 5 mg
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                  Description
                  OverviewNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
                  Catalogue Number05-23-0600
                  Brand Family Calbiochem®
                  SynonymsRPKPQQFFGLM
                  References
                  ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
                  Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
                  Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
                  Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
                  Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
                  Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
                  Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
                  Product Information
                  CAS number33507-63-0
                  ATP CompetitiveN
                  FormWhite solid
                  FormulationSupplied as a trifluoroacetate salt.
                  Hill FormulaC₆₃H₉₈N₁₈O₁₃S
                  Chemical formulaC₆₃H₉₈N₁₈O₁₃S
                  Hygroscopic Hygroscopic
                  ReversibleN
                  Sold on the basis of peptide contentY
                  Applications
                  Biological Information
                  Primary TargetSubstance P receptors
                  Purity≥96% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Peptide ContentY
                  Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Hygroscopic Hygroscopic
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  05-23-0600

                  References

                  Reference overview
                  Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
                  Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
                  Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
                  Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
                  Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
                  Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
                  Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision23-June-2008 RFH
                  SynonymsRPKPQQFFGLM
                  DescriptionNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
                  FormWhite solid
                  FormulationSupplied as a trifluoroacetate salt.
                  CAS number33507-63-0
                  Chemical formulaC₆₃H₉₈N₁₈O₁₃S
                  Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
                  Purity≥96% by HPLC
                  Solubility5% Acetic Acid (1 mg/ml)
                  Storage -20°C
                  Hygroscopic
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Toxicity Standard Handling
                  Merck USA index14, 8863
                  ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
                  Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
                  Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
                  Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
                  Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
                  Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
                  Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.