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GF128 | Stromal Cell-Derived Factor-1α Protein, Recombinant mouse

10 µg  
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      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Mouse E.coli Greater than 99% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of SDF-1 alpha.
      Catalogue NumberGF128
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionStromal Cell-Derived Factor-1α Protein, Recombinant mouse
      OverviewStromal Cell-Derived Factor-1 alpha (SDF-1 alpha) is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. Recombinant Mouse SDF-1 alpha is a 7.9 kDa protein containing 68 amino acid residues.
      Alternate Names
      • SDF-1alpha
      Product Information
      PresentationThe sterile filtered solution was lyophilized with no additives.
      ApplicationStromal Cell-Derived Factor-1 alpha protein (or SDF-1 alpha protein) is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 99% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of SDF-1 alpha.
      Specific ActivityDetermined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100ng/ml.
      Entrez Gene SummaryFor background information on chemokines, see CXCL11 (SCYB11; MIM 604852). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM]
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48061 # Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.
      SIZE: 93 amino acids; 10666 Da
      PTM: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
      SIMILARITY: SwissProt: P48061 ## Belongs to the intercrine alpha (chemokine CxC) family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted mouse SDF-1 alpha should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information

      Related Products & Applications

      Product Families


      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors