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12-543 | Src Substrate Peptide, biotin conjugate

1 mg  
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      Replacement Information
      Catalogue Number12-543
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSrc Substrate Peptide, biotin conjugate
      Product Information
      PresentationLyophilized powder
      ApplicationSrc Substrate Peptide, biotin conjugate primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • SRC
      • ASV
      • c-src
      • p60-Src
      • SRC1
      • c-SRC
      • pp60c-src
      Protein TargetSrc
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummarySIZE: 536 amino acids; 59835 Da
      SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
      PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
      SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated as a substrate for Src, active (Catalog # 14-326).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Src Substrate Peptide, biotin conjugate - 2426447 2426447
      Src Substrate Peptide, biotin conjugate - 2202711 2202711
      Src Substrate Peptide, biotin conjugate - 2322018 2322018
      Src Substrate Peptide, biotin conjugate - 26998 26998
      Src Substrate Peptide, biotin conjugate - 31824 31824
      Src Substrate Peptide, biotin conjugate - 33514 33514


      Reference overviewApplicationPub Med ID
      Contraction regulation of Akt in rat skeletal muscle
      Sakamoto, K., et al
      J Biol Chem, 277:11910-7 (2002) 2002

      Immunoblotting (Western)11809761 11809761
      Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells
      Szekeres, C. K., et al
      J Biol Chem, 275:38831-41 (2000) 2000

      Immunoblotting (Western)10952974 10952974
      A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases.
      Cheng, H C, et al.
      J. Biol. Chem., 267: 9248-56 (1992) 1992

      Show Abstract
      1577758 1577758

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      Alternative Format

      Catalog Number Description  
      12-140 Src Substrate Peptide Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates