324813 Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem

324813
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324813-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC50 = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.
          Catalogue Number324813
          Brand Family Calbiochem®
          SynonymsCDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea
          References
          ReferencesNewman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 1558.
          Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 2222.
          Morisseau, C., et al. 2002. Biochem. Pharmacol. 63, 1599.
          Imig, J.D., et al. 2002. Hypertension 39, 690.
          Argiriadi, M.A., et al. 2000. J. Biol. Chem. 275, 15265.
          Yu, Z., et al. 2000. Circ. Res. 87, 992.
          Product Information
          CAS number402939-18-8
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₉H₃₈N₂O
          Chemical formulaC₁₉H₃₈N₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSoluble epoxide hydrolase
          Primary Target IC<sub>50</sub>9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324813

          References

          Reference overview
          Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 1558.
          Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 2222.
          Morisseau, C., et al. 2002. Biochem. Pharmacol. 63, 1599.
          Imig, J.D., et al. 2002. Hypertension 39, 690.
          Argiriadi, M.A., et al. 2000. J. Biol. Chem. 275, 15265.
          Yu, Z., et al. 2000. Circ. Res. 87, 992.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          SynonymsCDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea
          DescriptionA cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC50 = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number402939-18-8
          Chemical formulaC₁₉H₃₈N₂O
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityCH₂Cl₂ (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesNewman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 1558.
          Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 2222.
          Morisseau, C., et al. 2002. Biochem. Pharmacol. 63, 1599.
          Imig, J.D., et al. 2002. Hypertension 39, 690.
          Argiriadi, M.A., et al. 2000. J. Biol. Chem. 275, 15265.
          Yu, Z., et al. 2000. Circ. Res. 87, 992.