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567565 | Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem

567565
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O 16037-91-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      567565-1GM
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          Glass bottle 1 gm
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          Description
          OverviewA pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.
          Catalogue Number567565
          Brand Family Calbiochem®
          SynonymsAntimony Sodium Gluconate, NaSbv, SSG, PTP Inhibitor XXIV, SHP1 Inhibitor IV
          References
          ReferencesWortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
          Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.
          Product Information
          CAS number16037-91-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
          Chemical formulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
          ReversibleY
          Structure formula Image
          Applications
          ApplicationSodium Stibogluconate, CAS 16037-91-5, is a pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase activity, including SHP-1, by forming a stable complex.
          Biological Information
          Primary TargetPTPase activity, including Src homology PTPase-1 (SHP-1)
          Primary Target IC<sub>50</sub>~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)
          Purity≥90% by titration on dry basis (≥30% Sb content)
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          567565

          References

          Reference overview
          Wortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
          Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.

          Brochure

          Title
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2008 RFH
          SynonymsAntimony Sodium Gluconate, NaSbv, SSG, PTP Inhibitor XXIV, SHP1 Inhibitor IV
          DescriptionA pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (ECmax = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (ECmax = 55 µM). Exhibits anti-leishmanial effects.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number16037-91-5
          Chemical formulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
          Structure formula
          Purity≥90% by titration on dry basis (≥30% Sb content)
          SolubilityH₂O (1 mg/ml). Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Standard Handling
          Merck USA index14, 701
          ReferencesWortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
          Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.