567430 Sodium Butyrate - CAS 156-54-7 - Calbiochem

567430
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₇O₂Na 156-54-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567430-250MG
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          Glass bottle 250 mg
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          Description
          OverviewA short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.
          Catalogue Number567430
          Brand Family Calbiochem®
          SynonymsButyric Acid, Na, NaB, HDAC Inhibitor V
          References
          ReferencesOu, H.C., et al. 1997. Neuroreport 8, 1375.
          Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
          Krupitza, G., et al. 1995. Carcinogenesis 16, 1199.
          Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31.
          Hague, A., et al. 1993. Int. J. Cancer 55, 498.
          Product Information
          CAS number156-54-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₄H₇O₂Na
          Chemical formulaC₄H₇O₂Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationSodium Butyrate, CAS 156-54-7, is a short chain fatty acid that induces apoptosis in colon carcinoma cells by a p53-independent pathway. Down-regulates the activity of casein kinase II in HT29 cells.
          Biological Information
          Primary TargetInduce apoptosis
          Purity≥98% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSET6400000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Sodium Butyrate - CAS 156-54-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Sodium Butyrate - CAS 156-54-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          567430

          References

          Reference overview
          Ou, H.C., et al. 1997. Neuroreport 8, 1375.
          Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
          Krupitza, G., et al. 1995. Carcinogenesis 16, 1199.
          Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31.
          Hague, A., et al. 1993. Int. J. Cancer 55, 498.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-September-2008 RFH
          SynonymsButyric Acid, Na, NaB, HDAC Inhibitor V
          DescriptionA short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.
          FormWhite solid
          CAS number156-54-7
          RTECSET6400000
          Chemical formulaC₄H₇O₂Na
          Structure formulaStructure formula
          Purity≥98% by titration
          SolubilityH₂O (2 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesOu, H.C., et al. 1997. Neuroreport 8, 1375.
          Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
          Krupitza, G., et al. 1995. Carcinogenesis 16, 1199.
          Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31.
          Hague, A., et al. 1993. Int. J. Cancer 55, 498.