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23-058M | Smurf1, active

23-058M
250 µg  
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      Overview

      Replacement Information
      Description
      Catalogue Number23-058M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSmurf1, active
      Alternate Names
      • SMAD ubiquitination regulatory factor 1
      • SMAD-specific E3 ubiquitin-protein ligase 1
      Background InformationSmurf1 is a member of the Nedd4-like family of E3 ligases. It contains an amino terminal C2 domain and 2 WW domains that are responsible for cellular localization and substrate recognition, and a catalytic carboxyl terminal HECT domain.
      Smurf1 was originally identified as a negative regulator of the TGF-β/BMP (bone morphogenetic proteins) signalling pathway by degrading SMAD proteins and TGF-β /BMP receptors. To date, over a dozen substrates have been identified, including Runx2, MEKK2, RhoA, Par6, JunB, Talin head, Prickle1, TRAF family proteins, and STAT1. This suggests a pleiotropic role for Smurf1 in various cellular functions such as bone homeostasis, embryonic development, cell movement and polarity control, and immune response. Aberrant expression of Smurfs has been shown to occur in several types of cancers, including breast, oesophageal, pancreatic and renal cell carcinomas.
      References
      Product Information
      Applications
      Key Applications
      • Enzyme Assay
      Biological Information
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications

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      Catalog Number Description  
      23-058 Smurf1, active Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases