566660 Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem

566660
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O 364590-63-6

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      566660-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          566660-5MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Glass bottle 5 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available.
              Catalogue Number566660
              Brand Family Calbiochem®
              SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
              References
              ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
              Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
              Chen, W., et al. 2004. Science 306, 2257.
              Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
              Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
              Product Information
              CAS number364590-63-6
              FormLight yellow solid
              Hill FormulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
              Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
              Hygroscopic Hygroscopic
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Purity≥98% by HPLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem Certificates of Analysis

              TitleLot Number
              566660

              References

              Reference overview
              Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
              Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
              Chen, W., et al. 2004. Science 306, 2257.
              Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
              Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.

              Citations

              Title
            • Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision27-February-2012 RFH
              SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
              DescriptionA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
              FormLight yellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number364590-63-6
              Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (10 mg/ml) or H₂O (25 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
              Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
              Chen, W., et al. 2004. Science 306, 2257.
              Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
              Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
              Citation
            • Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.