566320 Sirtinol - CAS 410536-97-9 - Calbiochem

566320
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₂N₂O₂ 410536-97-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      566320-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1 (IC50 = 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively). Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM), and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 70 µM and 40 µM, respectively). A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566321) in DMSO is also available.
          Catalogue Number566320
          Brand Family Calbiochem®
          Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
          References
          ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
          Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.
          Product Information
          CAS number410536-97-9
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₆H₂₂N₂O₂
          Chemical formulaC₂₆H₂₂N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHuman HDAC1
          Primary Target IC<sub>50</sub>48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Sirtinol - CAS 410536-97-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Sirtinol - CAS 410536-97-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          566320

          References

          Reference overview
          Mai, A., et al. 2005. J. Med. Chem. 48, 7789.
          Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
          DescriptionA cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number410536-97-9
          Chemical formulaC₂₆H₂₂N₂O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
          Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.