567060 Siomycin A, Streptomyces sioyaensis - Calbiochem

567060
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₇₁H₈₁N₁₉O₁₈S₅

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567060-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
          Catalogue Number567060
          Brand Family Calbiochem®
          SynonymsNSC 285116, FOXM1 Inhibitor II
          References
          ReferencesPriller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
          Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
          Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
          Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
          Product Information
          FormWhite solid
          Hill FormulaC₇₁H₈₁N₁₉O₁₈S₅
          Chemical formulaC₇₁H₈₁N₁₉O₁₈S₅
          Applications
          ApplicationSiomycin A, Streptomyces sioyaensis, CAS 12656-09-6, is a cell-permeable macrocyclic antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-24/25-36/37-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Siomycin A, Streptomyces sioyaensis - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Siomycin A, Streptomyces sioyaensis - Calbiochem Certificates of Analysis

          TitleLot Number
          567060

          References

          Reference overview
          Priller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
          Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
          Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
          Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-November-2011 JSW
          SynonymsNSC 285116, FOXM1 Inhibitor II
          DescriptionA cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₇₁H₈₁N₁₉O₁₈S₅
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesPriller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
          Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
          Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
          Lentzen, G., et al. 2003. Chem. Biol. 10, 769.