567021 Simvastatin, Sodium Salt - Calbiochem

567021
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₅H₃₉O₆ • Na

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567021-50MG
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          Glass bottle 50 mg
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          567021-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
              Catalogue Number567021
              Brand Family Calbiochem®
              SynonymsL-Type Calcium Channel Blocker VI
              References
              ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
              Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
              Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
              Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
              Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
              Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
              Product Information
              ATP CompetitiveN
              FormBeige solid
              Hill FormulaC₂₅H₃₉O₆ • Na
              Chemical formulaC₂₅H₃₉O₆ • Na
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Simvastatin, Sodium Salt - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Simvastatin, Sodium Salt - Calbiochem Certificates of Analysis

              TitleLot Number
              567021

              References

              Reference overview
              Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
              Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
              Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
              Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
              Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
              Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision13-October-2015 JSW
              SynonymsL-Type Calcium Channel Blocker VI
              DescriptionCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
              FormBeige solid
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₂₅H₃₉O₆ • Na
              Structure formulaStructure formula
              Purity≥97% by HPLC
              SolubilityDMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Standard Handling
              ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
              Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
              Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
              Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
              Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
              Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.