533065 Seriniquinone - Calbiochem

533065
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₈O₄S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33065.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable dinaphthothiophenetetraone compound isolated from marine bacterium of the genus Serinicoccus that targets dermicidin and displays anti-cancer property against a wide range of cancer cell lines (mean GI = 758 nM, LC50 = 13.2 µM in NCI-60 panel). Exhibits highest potency against melanoma cell lines. Following its uptake it localizes rapidly into endoplasmic reticulum and induces autophagocytosis as evidenced by increased conversion of LC3A-I and LC3B-I to LC3A-II and LC3B-II, respectively. Also shown to induce apoptosis in HCT-116 cells with increase in caspase-3, 7, and 9 activation and cleavage of poly(ADP-ribose) polymerase.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533065
          Brand Family Calbiochem®
          SynonymsDinaphtho[2,3-b:2ʹ,3ʹ-d]thiophene-5,7,12,13-tetraone, Autophagy Inducer, Seriniquinone
          DescriptionSeriniquinone
          References
          ReferencesTrzoss, L., et al. 2014. PNAS. 111, 14687.
          Product Information
          FormYellow solid
          Hill FormulaC₂₀H₈O₄S
          Chemical formulaC₂₀H₈O₄S
          ReversibleY
          Applications
          Biological Information
          Primary Targetdermicidin
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Seriniquinone - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Trzoss, L., et al. 2014. PNAS. 111, 14687.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2016 JSW
          SynonymsDinaphtho[2,3-b:2ʹ,3ʹ-d]thiophene-5,7,12,13-tetraone, Autophagy Inducer, Seriniquinone
          DescriptionA cell permeable dinaphthothiophenetetraone compound isolated from marine bacterium of the genus Serinicoccus that targets dermicidin and displays anti-cancer property against a wide range of cancer cell lines (mean GI = 758 nM, LC50 = 13.2 µM in NCI-60 panel). Exhibits highest potency against melanoma cell lines. Following its uptake it localizes rapidly into endoplasmic reticulum and induces autophagocytosis as evidenced by increased conversion of LC3A-I and LC3B-I to LC3A-II and LC3B-II, respectively. Also shown to induce apoptosis in HCT-116 cells with increase in caspase-3, 7, and 9 activation and cleavage of poly(ADP-ribose) polymerase.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₈O₄S
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTrzoss, L., et al. 2014. PNAS. 111, 14687.