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563080 | Salinomycin

563080
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₂H₇₀O₁₁ 53003-10-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      563080-2MG
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          2 mg
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          Description
          OverviewSalinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
          Catalogue Number563080
          Brand Family Calbiochem®
          References
          ReferencesGupta, P.B., et al. 2009. Cell. 138, 1.
          Product Information
          CAS number53003-10-4
          FormWhite solid
          Hill FormulaC₄₂H₇₀O₁₁
          Chemical formulaC₄₂H₇₀O₁₁
          Hygroscopic Hygroscopic
          Structure formula Image
          Applications
          Biological Information
          Purity≥96% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 45

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          563080

          References

          Reference overview
          Gupta, P.B., et al. 2009. Cell. 138, 1.

          Brochure

          Title
          Ionophores Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2010 RFH
          DescriptionSalinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
          FormWhite solid
          CAS number53003-10-4
          Chemical formulaC₄₂H₇₀O₁₁
          Structure formula
          Purity≥96% by HPLC
          SolubilityMethanol (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          Merck USA index13, 8415
          ReferencesGupta, P.B., et al. 2009. Cell. 138, 1.