572632 SU5614 - CAS 186611-56-3 - Calbiochem

572632
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₃N₂OCl 186611-56-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      572632-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
          Catalogue Number572632
          Brand Family Calbiochem®
          Synonyms5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX
          References
          ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
          Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
          Product Information
          CAS number186611-56-3
          ATP CompetitiveY
          DeclarationNot available for sale in the United States.
          FormOrange-red solid
          Hill FormulaC₁₅H₁₃N₂OCl
          Chemical formulaC₁₅H₁₃N₂OCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetVEGF Flk-1
          Primary Target IC<sub>50</sub>1.2 µM, 2.9 µM against VEGF (Flk-1) and PDGF receptor tyrosine kinases, respectively; ≤680 nM against the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SU5614 - CAS 186611-56-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SU5614 - CAS 186611-56-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          572632

          References

          Reference overview
          Cools, J., et al. 2004. Cancer Res. 64, 6385.
          Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX
          DescriptionA potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
          FormOrange-red solid
          CAS number186611-56-3
          Chemical formulaC₁₅H₁₃N₂OCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
          Sun, L., et al. 1998. J. Med. Chem. 41, 2588.