573108 STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem

573108
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₁N₃O₃ 285986-31-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      573108-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
          Catalogue Number573108
          Brand Family Calbiochem®
          SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
          References
          ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.
          Product Information
          CAS number285986-31-4
          FormWhite solid
          Hill FormulaC₁₆H₁₁N₃O₃
          Chemical formulaC₁₆H₁₁N₃O₃
          Structure formula ImageStructure formula Image
          Applications
          ApplicationSTAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          573108

          References

          Reference overview
          Muller, J., et al. 2008. ChemBioChem 9, 723.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-May-2011 RFH
          SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
          DescriptionA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number285986-31-4
          Chemical formulaC₁₆H₁₁N₃O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.