573099 STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

573099
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₅NO₄S 19983-44-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      573099-25MG
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          Plastic Bag(s) 25 mg
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          Description
          OverviewA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
          Catalogue Number573099
          Brand Family Calbiochem®
          Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
          References
          ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.
          Product Information
          CAS number19983-44-9
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₈H₅NO₄S
          Chemical formulaC₈H₅NO₄S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSTAT3
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          573099

          References

          Reference overview
          Schust, J., et al. 2006. Chem. Biol. 13, 1235.

          Brochure

          Title
          Pathways and Biomarkers of JAK/STAT Signaling
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-June-2007 JSW
          Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
          DescriptionA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number19983-44-9
          Chemical formulaC₈H₅NO₄S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
          Toxicity Irritant
          ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.