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SF-914 | SOX2; Human, Cyanine3 RNA Detection Probe | SmartFlare

250 reactions  
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      Replacement Information

      Key Specifications Table

      Entrez Gene NumberSpecies Reactivity
      NM_003106.3 H
      Catalogue NumberSF-914
      Trade Name
      • SmartFlare
      DescriptionSOX2; Human, Cyanine3 RNA Detection Probe | SmartFlare
      OverviewSmartFlare is a fluorescent reagent that when added to live cells enables sequence-specific mRNA and microRNA's expression detection at single cell resolution – which can reveal new insights that lysed methods giving bulk average measurements may hide. The probes do not harm the live cells allowing researchers to not only identify cells expressing biomarkers of interest, but also enrich and sort cells based on individual expression levels through FACS. Additionally, treatment of cells with SmartFlare is compatible with downstream functional analysis, especially important for preserving precious samples.
      Alternate Names
      • ANOP3
      • MCOPS3
      Background InformationSOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
      Product Information
      FormatCyanine 3
      ApplicationWith SmartFlare™ RNA Detection probes, you can detect RNA in live cells. With an overnight incubation of SOX2; Human, Cyanine3 RNA Detection Probe you can detect the presence of SOX2 within your cells.
      Key Applications
      • RNA Detection
      Biological Information
      Species Reactivity
      • Human
      Entrez Gene Number
      Gene Symbol
      • SOX2
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceSmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C in lyophilized format ONLY. Room temperature is required for reconstituted product.
      Packaging Information
      Material Size250 reactions
      Transport Information
      Supplemental Information