567693 SOST, Mouse, Recombinant

567693
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥90% by SDS-PAGE

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567693-25UG
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      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Will advise
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          Glass bottle 25 μg
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          Description
          OverviewRecombinant, mouse sclerostin (SOST) consisting of amino acids 24-211, expressed in NS0-derived murine myeloma cells with an N-terminal His•Tag®. SOST is expressed by osteoclasts in developing bones of mouse embryos and acts as a negative regulator of bone formation through repression of BMP-induced osteogenesis.
          Catalogue Number567693
          Brand Family Calbiochem®
          References
          ReferencesKusu, N. et al. 2003. J. Biol. Chem. 278, 24113.
          Balemans, W. et al. 2001. Hum. Mol. Genet. 10 537.
          Brunkow, M.E. et al. 2001. Am. J. Hum. Genet. 68, 577.
          Product Information
          FormSolid
          FormulationLyophilized from 0.2 µm filter-sterilized PBS, BSA.
          Applications
          Biological Information
          Biological activityInhibition Assay: Inhibits hBMP-6-induced alkaline phosphatase by 50-80% in MC3T3-E1 mouse osteoblastic cells when used at a concentration of 30 µg/ml.
          Purity≥90% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <1.0 EU/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SOST, Mouse, Recombinant SDS

          Title

          Safety Data Sheet (SDS) 

          SOST, Mouse, Recombinant Certificates of Analysis

          TitleLot Number
          567693

          References

          Reference overview
          Kusu, N. et al. 2003. J. Biol. Chem. 278, 24113.
          Balemans, W. et al. 2001. Hum. Mol. Genet. 10 537.
          Brunkow, M.E. et al. 2001. Am. J. Hum. Genet. 68, 577.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-Sepmtember-2011 RFH
          DescriptionRecombinant, mouse sclerostin (SOST) consisting of amino acids 24-211, expressed in NS0-derived murine myeloma cells with an N-terminal His•Tag®. SOST is expressed by osteoclasts in developing bones of mouse embryos and acts as a negative regulator of bone formation through repression of BMP-induced osteogenesis.
          FormSolid
          FormulationLyophilized from 0.2 µm filter-sterilized PBS, BSA.
          Purity≥90% by SDS-PAGE
          ContaminantsEndotoxin: <1.0 EU/µg protein
          Biological activityInhibition Assay: Inhibits hBMP-6-induced alkaline phosphatase by 50-80% in MC3T3-E1 mouse osteoblastic cells when used at a concentration of 30 µg/ml.
          SolubilityReconstitute to 200 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKusu, N. et al. 2003. J. Biol. Chem. 278, 24113.
          Balemans, W. et al. 2001. Hum. Mol. Genet. 10 537.
          Brunkow, M.E. et al. 2001. Am. J. Hum. Genet. 68, 577.