566326 SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem

566326
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₁₃Cl₂N₃O₂ 304896-21-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      566326-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
          Catalogue Number566326
          Brand Family Calbiochem®
          SynonymsSIRT2 Inhibitor I, Inactive Control
          References
          ReferencesOuterio, T.F., et al. 2007. Science 317, 516.
          Product Information
          CAS number304896-21-7
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₃H₁₃Cl₂N₃O₂
          Chemical formulaC₂₃H₁₃Cl₂N₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSirtuin 3
          Primary Target IC<sub>50</sub>>5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          566326

          References

          Reference overview
          Outerio, T.F., et al. 2007. Science 317, 516.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-December-2007 JSW
          SynonymsSIRT2 Inhibitor I, Inactive Control
          DescriptionA cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number304896-21-7
          Chemical formulaC₂₃H₁₃Cl₂N₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesOuterio, T.F., et al. 2007. Science 317, 516.