566324 SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

566324
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₁₃Cl₂N₃O₂ 304896-28-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      566324-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
          Catalogue Number566324
          Brand Family Calbiochem®
          Synonyms2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
          References
          ReferencesOuterio, T.F., et al. 2007. Science 317, 516.
          Product Information
          CAS number304896-28-4
          FormYellow solid
          Hill FormulaC₂₃H₁₃Cl₂N₃O₂
          Chemical formulaC₂₃H₁₃Cl₂N₃O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          566324

          References

          Reference overview
          Outerio, T.F., et al. 2007. Science 317, 516.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-March-2008 RFH
          Synonyms2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
          DescriptionA cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number304896-28-4
          Chemical formulaC₂₃H₁₃Cl₂N₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (2.5 mg/ml). Slight warming may be required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesOuterio, T.F., et al. 2007. Science 317, 516.