565840 SHIP2 Inhibitor, AS1938909 - Calbiochem

565840
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₁₃Cl₂F₂NO₂S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565840-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki = 0.44 µM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50 = 0.18, 0.57, 21, > 50, > 50 and > 50 µM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available (Cat. No. 565835).
          Catalogue Number565840
          Brand Family Calbiochem®
          Synonyms3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) Inhibitor, AS1938909
          References
          ReferencesSuwa, A., et al. 2010. Eur. J. Pharmacol. 642, 177.
          Suwa, A., et al. 2009. Br. J. Pharmacol. 158, 879.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₉H₁₃Cl₂F₂NO₂S
          Chemical formulaC₁₉H₁₃Cl₂F₂NO₂S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SHIP2 Inhibitor, AS1938909 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SHIP2 Inhibitor, AS1938909 - Calbiochem Certificates of Analysis

          TitleLot Number
          565840

          References

          Reference overview
          Suwa, A., et al. 2010. Eur. J. Pharmacol. 642, 177.
          Suwa, A., et al. 2009. Br. J. Pharmacol. 158, 879.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-August-2018 JSW
          Synonyms3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) Inhibitor, AS1938909
          DescriptionA cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki = 0.44 µM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50 = 0.18, 0.57, 21, > 50, > 50 and > 50 µM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available (Cat. No. 565835).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₁₃Cl₂F₂NO₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSuwa, A., et al. 2010. Eur. J. Pharmacol. 642, 177.
          Suwa, A., et al. 2009. Br. J. Pharmacol. 158, 879.