Key Specifications Table
Pricing & Availability
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|565835-10MG||Glass bottle||10 mg||
|Overview||A cell-permeable steroidal compound that selectively inhibits SHIP1′ polyphosphatase activity toward PI(3,4,5)P3 (IC50 = 10 µM), but not SHIP2 5′ or PTEN′ polyphosphatase activity toward PI(3,4,5)P3 (IC50 > 1 mM). Effectively inhibits SHIP1-mediated immune response both in vitro and in vivo, as well as SHIP1-dependent cancer cell survival. SHIP2 Inhibitor, AS1938909 is also available (Cat. No. 565840).|
|Synonyms||3α-Aminocholestane, SH2-domain-containing inositol 5ʹ-phosphatase 1 (SHIP1) Inhibitor, 3AC|
|References||Brooks, R., et al. 2010. J. Immunol. 184, 3582.|
|Structure formula Image|
|Application||SHIP1 Inhibitor, 3AC, CAS 2206-20-4, is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 µM), but has no effect on SHIP2 5′ or PTEN activity on PIP3.|
|Purity||≥98% by 1H NMR|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Brooks, R., et al. 2010. J. Immunol. 184, 3582.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.