505484 SB-277011-A Dihydrochloride - CAS 1226917-67-4 - Calbiochem

505484
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₃₀N₄O•2HCl 1226917-67-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05484.0001
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          Glass bottle 5 mg
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          Description
          OverviewA brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
          Catalogue Number505484
          Brand Family Calbiochem®
          SynonymsSB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
          References
          ReferencesCollins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
          Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.
          Product Information
          CAS number1226917-67-4
          FormWhite solid
          Hill FormulaC₂₈H₃₀N₄O•2HCl
          Chemical formulaC₂₈H₃₀N₄O•2HCl
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetD3
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
          Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2013 JSW
          SynonymsSB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
          DescriptionA brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
          FormWhite solid
          CAS number1226917-67-4
          Chemical formulaC₂₈H₃₀N₄O•2HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCollins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
          Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.