559408 SB 220025, Trihydrochloride - CAS 197446-75-6 - Calbiochem

559408
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      559408-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
          Catalogue Number559408
          Brand Family Calbiochem®
          Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
          References
          ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
          Wang, Z., et al. 1998. Structure 6, 1117.
          Product Information
          CAS number197446-75-6
          FormWhite solid
          Hill FormulaC₁₈H₁₉FN₆ • 3HCl
          Chemical formulaC₁₈H₁₉FN₆ • 3HCl
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SB 220025, Trihydrochloride - CAS 197446-75-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
          Wang, Z., et al. 1998. Structure 6, 1117.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-September-2014 JSW
          Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
          DescriptionA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number197446-75-6
          Chemical formulaC₁₈H₁₉FN₆ • 3HCl
          Purity≥98% by HPLC
          SolubilityH₂O (22 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
          Wang, Z., et al. 1998. Structure 6, 1117.