559393 SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem

559393
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₄FN₃O · HCl 350228-36-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      559393-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
          Catalogue Number559393
          Brand Family Calbiochem®
          Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
          References
          Product Information
          CAS number350228-36-3
          ATP CompetitiveY
          FormAmber solid
          Hill FormulaC₂₀H₁₄FN₃O · HCl
          Chemical formulaC₂₀H₁₄FN₃O · HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp38β
          Primary Target IC<sub>50</sub>350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
          Primary Target K<sub>i</sub>16 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          559393

          Citations

          Title
        • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
          DescriptionA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
          FormAmber solid
          CAS number350228-36-3
          Chemical formulaC₂₀H₁₄FN₃O · HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO or slightly soluble in H₂O (0.5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
          Toxicity Standard Handling
          Citation
        • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Related Products & Applications

          Alternative Products

          Catalog Number Description  
          559388 SB 202190 - CAS 152121-30-7 - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors