559388 SB 202190 - CAS 152121-30-7 - Calbiochem

559388
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₄FN₃O 152121-30-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      559388-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
          Catalogue Number559388
          Brand Family Calbiochem®
          Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II
          References
          ReferencesDavies, S.P., et al. 2000. Biochem. J. 351, 95.
          Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
          Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
          Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
          Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
          Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
          Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
          Lee, J.C., et al. 1994. Nature 372, 739.
          Product Information
          CAS number152121-30-7
          ATP CompetitiveY
          FormPale yellow solid
          Hill FormulaC₂₀H₁₄FN₃O
          Chemical formulaC₂₀H₁₄FN₃O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp38β
          Primary Target IC<sub>50</sub>350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
          Primary Target K<sub>i</sub>16 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SB 202190 - CAS 152121-30-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SB 202190 - CAS 152121-30-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          559388

          References

          Reference overview
          Davies, S.P., et al. 2000. Biochem. J. 351, 95.
          Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
          Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
          Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
          Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
          Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
          Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
          Lee, J.C., et al. 1994. Nature 372, 739.

          Brochure

          Title
          MAPK Pathway Poster ( 750 KB )

          Citations

          Title
        • Annika Grabbe and Jurgen Wienands. (2006) Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood 108, 3761-3768.
        • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-January-2010 RFH
          Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II
          DescriptionA potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells.
          FormPale yellow solid
          CAS number152121-30-7
          Chemical formulaC₂₀H₁₄FN₃O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDavies, S.P., et al. 2000. Biochem. J. 351, 95.
          Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
          Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
          Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
          Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
          Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
          Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
          Lee, J.C., et al. 1994. Nature 372, 739.
          Citation
        • Annika Grabbe and Jurgen Wienands. (2006) Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood 108, 3761-3768.
        • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors