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12-355 | SAMS Peptide

12-355
250 µg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-355
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSAMS Peptide
      References
      Product Information
      Presentationsterile distilled water
      Applications
      ApplicationSAMS Peptide primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
      Gene Symbol
      • MAT1A
      • SAMS
      • AMS1
      • MAT
      • MATA1
      • SAMS1
      • MAT-I/III
      Protein TargetAMPK (α1, β1, γ1)
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q00266 # Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
      COFACTOR: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity). & Binds 1 potassium ion per subunit (By similarity).
      SIZE: 395 amino acids; 43648 Da
      SUBUNIT: Homotetramer (MAT-I) or homodimer (MAT-III).
      TISSUE SPECIFICITY: Expressed in liver.
      DISEASE: SwissProt: Q00266 # Defects in MAT1A are a cause of a form of hypermethioninemia [MIM:250850]; also called MAT I/III deficiency. The disease is characterized by fetid breath and dimethylsulfide excretion. Most mutations are transmitted in an autosomal recessive manner, but autosomal dominant inheritance has also been observed. The clinical consequences of hypermethioninemia are poorly understood. In some individuals, hypermethioninemia is apparently benign; in others, association of neurological problems with null mutations has been observed.
      SIMILARITY: SwissProt: Q00266 ## Belongs to the AdoMet synthetase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Peptide Phosphorylation Assay. SAMS Peptide was phosphorylated by AMP activated enzyme in the presence and absence of AMP.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      SAMS Peptide (substrate for AMP-activated Protein Kinase) - 2275600 2275600
      SAMS Peptide (substrate for AMP-activated Protein Kinase) - JBC1946385 JBC1946385
      SAMS Peptide - 17996 17996
      SAMS Peptide - 20823 20823
      SAMS Peptide - 21429 21429
      SAMS Peptide - 23741 23741
      SAMS Peptide - 25209 25209
      SAMS Peptide - 27927 27927
      SAMS Peptide - 27964 27964
      SAMS Peptide - 31602 31602
      SAMS Peptide - DAM1687551 DAM1687551
      SAMS Peptide - DAM1692637 DAM1692637
      SAMS Peptide - DAM1739175 DAM1739175
      SAMS Peptide - DAM1747358 DAM1747358
      SAMS Peptide - DAM1751943 DAM1751943
      SAMS Peptide - DAM1772431 DAM1772431
      SAMS Peptide -2594395 2594395

      References

      Reference overviewApplicationPub Med ID
      Activation of 5'AMP-activated kinase is mediated through c-Src and PI-3 kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: role of peroxynitrite
      Zou, M. H., et al
      J Biol Chem, 278:34003-34010 (2003) 2003

      Kinase Assay12824177 12824177
      The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
      Hardie, D G, et al.
      Annu. Rev. Biochem., 67: 821-55 (1998) 1998

      Show Abstract
      9759505 9759505
      Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay.
      Davies, S P, et al.
      Eur. J. Biochem., 186: 123-8 (1989) 1989

      Show Abstract
      2574667 2574667
      Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.
      Carling, D, et al.
      Eur. J. Biochem., 186: 129-36 (1989) 1989

      Show Abstract
      2598924 2598924

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates