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20-122 | S6 Kinase Substrate Cocktail

1 mL  
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      Key Specifications Table

      Key Applications
      Catalogue Number20-122
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionS6 Kinase Substrate Cocktail
      Product Information
      Presentation20mM MOPS, pH 7.2, 25mM β-glycerophosphate, 5mM EGTA, 1mM sodium orthovanadate, 1mM dithiothreitol.
      Key Applications
      • Kinase Assay
      Application NotesFor use in kinase assays.
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
      Gene Symbol
      • RPS6KA1
      • pp90RSK1
      • HU-1
      • RSK-1
      • MAPKAPK1A
      • p90S6K
      • RSK1
      • RSK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UK32 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
      COFACTOR: Magnesium (By similarity).
      SIZE: 745 amino acids; 83872 Da
      SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
      PTM: Autophosphorylated on Ser-389, as part of the activation process (By similarity).
      SIMILARITY: SwissProt: Q9UK32 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size1 mL
      Transport Information
      Supplemental Information