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557370 | Rottlerin - CAS 82-08-6 - Calbiochem

557370
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₂₈O₈ 82-08-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      557370-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
          Catalogue Number557370
          Brand Family Calbiochem®
          SynonymsMallotoxin
          References
          ReferencesVillalba, M., et al. 1999. J. Immunol. 163, 5813.
          Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
          Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
          Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
          Product Information
          CAS number82-08-6
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₃₀H₂₈O₈
          Chemical formulaC₃₀H₂₈O₈
          ReversibleY
          Structure formula Image
          Applications
          ApplicationRottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes.
          Biological Information
          Primary TargetPKCδ
          Primary Target IC<sub>50</sub>3-6 µM against PKCδ; 5.3 µM against CaM kinase III
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSAM6913800
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          557370

          References

          Reference overview
          Villalba, M., et al. 1999. J. Immunol. 163, 5813.
          Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
          Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
          Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )

          Citations

          Title
        • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
        • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
        • Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          SynonymsMallotoxin
          DescriptionA cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCΘ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
          FormOrange solid
          CAS number82-08-6
          RTECSAM6913800
          Chemical formulaC₃₀H₂₈O₈
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (30 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 8272
          ReferencesVillalba, M., et al. 1999. J. Immunol. 163, 5813.
          Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
          Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
          Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
          Citation
        • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
        • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
        • Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.