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557550 | Ro106-9920

557550
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₇N₅OS 62645-28-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      557550-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Blocks NF-κB-dependent cytokine expression in human PBMNs (IC50’s = ~ 700 nM for TNF-α, IL-1β, and IL-6 inhibition) and rats. Does not inhibit SCFβTRCP(IκBα ubiquitin ligase)-mediated β-catenin ubiquitination in Jurkat cells. At 10 µM concentrations, also inhibits the activities of 5-lipoxygenase (by 89%) and EGFR kinase (by 63%).
          Catalogue Number557550
          Brand Family Calbiochem®
          References
          ReferencesSwinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
          Product Information
          CAS number62645-28-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₇N₅OS
          Chemical formulaC₁₀H₇N₅OS
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetIκBαee ubiquitination
          Primary Target IC<sub>50</sub>2.3 µM against IκBαee ubiquitination
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          557550

          References

          Reference overview
          Swinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2009 JSW
          DescriptionA cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Also reported to prevent degradation of IκBαee in MM6 cells (complete inhibition at ~3-5 µM). Shown to block NF-κB-dependent cytokine expression in human peripheral blood mononuclear cells (PBMN) (IC50 = 600-700 nM for TNF-α, IL-1β, and IL-6 inhibition). Also shown to lower circulating levels of TNFα in LPS-treated rats. Also shown to inhibit 5-lipoxygenase (89% inhibition) and EGFR kinase (63% inhibition) at higher concentrations (10 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number62645-28-7
          Chemical formulaC₁₀H₇N₅OS
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml) or Ethanol (1 mg/ml)
          Storage ≤ -70°C
          Protect from light
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Toxicity Standard Handling
          ReferencesSwinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.