557508 Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem

557508
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O 125313-65-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557508-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
          Catalogue Number557508
          Brand Family Calbiochem®
          Synonyms2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate
          References
          ReferencesZhang, C., et al. 1997. J. Immunol. 158, 4968.
          Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
          Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Product Information
          CAS number125313-65-7
          ATP CompetitiveY
          FormRed to reddish-orange solid
          Hill FormulaC₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
          Chemical formulaC₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetrat brain PKC
          Primary Target IC<sub>50</sub>158 nM against rat brain PKC; 53 nM for PKCα, 195 nM for PKCβ, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε
          Purity≥93% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          557508

          References

          Reference overview
          Zhang, C., et al. 1997. J. Immunol. 158, 4968.
          Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
          Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          Synonyms2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate
          DescriptionA cell-permeable, reversible, selective protein kinase C (PKC) inhibitor that acts at the ATP binding site of PKC (IC50 = 158 nM for rat brain PKC). Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1 unlike staurosporine and other serine/threonine kinase inhibitors. IC50 values for individual PKC isozymes are as follows: 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε. Inhibits carbachol-evoked noradrenaline release (IC50 = 0.6 µM).
          FormRed to reddish-orange solid
          CAS number125313-65-7
          Chemical formulaC₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
          Structure formulaStructure formula
          Purity≥93% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesZhang, C., et al. 1997. J. Immunol. 158, 4968.
          Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
          Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.