553509 Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

553509
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₂₀N₄O₃ 171927-40-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553509-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
          Catalogue Number553509
          Brand Family Calbiochem®
          Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
          References
          ReferencesHuber, K. V. M., et al. 2014. Nature In press.
          He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
          Walsh, A.B., et al. 1997. Oncogene 15, 2553.
          Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
          Product Information
          CAS number171927-40-5
          ATP CompetitiveN
          FormLight-yellow solid
          Hill FormulaC₁₆H₂₀N₄O₃
          Chemical formulaC₁₆H₂₀N₄O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationRas/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.
          Biological Information
          Primary TargetRas/Rac
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          553509

          References

          Reference overview
          Huber, K. V. M., et al. 2014. Nature In press.
          He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
          Walsh, A.B., et al. 1997. Oncogene 15, 2553.
          Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2014 JSW
          Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
          DescriptionA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
          FormLight-yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number171927-40-5
          Chemical formulaC₁₆H₂₀N₄O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHuber, K. V. M., et al. 2014. Nature In press.
          He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
          Walsh, A.B., et al. 1997. Oncogene 15, 2553.
          Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.