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553210 | Rapamycin - CAS 53123-88-9 - Calbiochem

553210
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₁H₇₉NO₁₃ 53123-88-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      553210-100UG
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          Glass bottle 100 μg
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          553210-10MG
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              Glass bottle 10 mg
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              553210-1MG
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                  Glass bottle 1 mg
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                  553210-5MG
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                      Glass bottle 5 mg
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                      Description
                      OverviewAnti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
                      Catalogue Number553210
                      Brand Family Calbiochem®
                      SynonymsmTOR Inhibitor I
                      References
                      ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
                      Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                      Braun, W., et al. 1995. FASEB J. 9, 63.
                      Nielsen, F.C., et al. 1995. Nature 377, 358.
                      Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                      Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                      Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                      Kuo, J., et al. 1992. Nature 358, 70.
                      Price, D.J., et al. 1992. Science 257, 973.
                      Heitman, J., et al. 1991. Science 253, 905.
                      Kay, J.E., et al. 1991. Immunology 72, 544.
                      Schreiber, S.L. 1991. Science 251, 283.
                      Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                      Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
                      Product Information
                      CAS number53123-88-9
                      ATP CompetitiveN
                      FormClear film
                      Hill FormulaC₅₁H₇₉NO₁₃
                      Chemical formulaC₅₁H₇₉NO₁₃
                      ReversibleN
                      Structure formula Image
                      Applications
                      Biological Information
                      Primary TargetMammalian target of rapamycin (mTOR)
                      Primary Target IC<sub>50</sub>50 pM against p70 S6 kinase
                      Purity≥99% by HPLC
                      Physicochemical Information
                      Cell permeableN
                      Dimensions
                      Materials Information
                      Toxicological Information
                      Safety Information according to GHS
                      RTECSVE6250000
                      Safety Information
                      Product Usage Statements
                      Storage and Shipping Information
                      Ship Code Ambient Temperature Only
                      Toxicity Standard Handling
                      Storage -20°C
                      Do not freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                      Packaging Information
                      Transport Information
                      Supplemental Information
                      Specifications

                      Documentation

                      SDS

                      Title

                      Safety Data Sheet (SDS) 

                      Certificates of Analysis

                      TitleLot Number
                      553210

                      References

                      Reference overview
                      Chen, T., et al. 2011. Aging Cell. 10, 908.
                      Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                      Braun, W., et al. 1995. FASEB J. 9, 63.
                      Nielsen, F.C., et al. 1995. Nature 377, 358.
                      Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                      Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                      Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                      Kuo, J., et al. 1992. Nature 358, 70.
                      Price, D.J., et al. 1992. Science 257, 973.
                      Heitman, J., et al. 1991. Science 253, 905.
                      Kay, J.E., et al. 1991. Immunology 72, 544.
                      Schreiber, S.L. 1991. Science 251, 283.
                      Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                      Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

                      Citations

                      Title
                    • Chen, T., et al. 2011. Aging Cell. 10, 908.
                    • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
                    • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
                    • Liao, X., et al. 2003. Endocrinology 144, 1656.
                    • Data Sheet

                      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                      Revision11-September-2014 JSW
                      SynonymsmTOR Inhibitor I
                      DescriptionSelectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
                      FormClear film
                      CAS number53123-88-9
                      RTECSVE6250000
                      Chemical formulaC₅₁H₇₉NO₁₃
                      Structure formula
                      Purity≥99% by HPLC
                      SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
                      Storage -20°C
                      Do Not Freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                      Toxicity Standard Handling
                      Merck USA index14, 8114
                      ReferencesChen, T., et al. 2011. Aging Cell. 10, 908.
                      Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
                      Braun, W., et al. 1995. FASEB J. 9, 63.
                      Nielsen, F.C., et al. 1995. Nature 377, 358.
                      Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
                      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
                      Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
                      Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
                      Kuo, J., et al. 1992. Nature 358, 70.
                      Price, D.J., et al. 1992. Science 257, 973.
                      Heitman, J., et al. 1991. Science 253, 905.
                      Kay, J.E., et al. 1991. Immunology 72, 544.
                      Schreiber, S.L. 1991. Science 251, 283.
                      Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
                      Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
                      Citation
                    • Chen, T., et al. 2011. Aging Cell. 10, 908.
                    • Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.
                    • Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.
                    • Liao, X., et al. 2003. Endocrinology 144, 1656.