553502 Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

553502
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₃₈Cl₃N₇ 1177865-17-6

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553502-10MG
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          Glass bottle 10 mg
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          553502-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
              Catalogue Number553502
              Brand Family Calbiochem®
              SynonymsNSC23766
              References
              ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
              Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
              Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
              Product Information
              CAS number1177865-17-6
              ATP CompetitiveN
              FormLyophilized
              Hill FormulaC₂₄H₃₈Cl₃N₇
              Chemical formulaC₂₄H₃₈Cl₃N₇
              Hygroscopic Hygroscopic
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetRac1
              Primary Target IC<sub>50</sub>~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
              Purity≥93% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Certificates of Analysis

              TitleLot Number
              553502

              References

              Reference overview
              Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
              Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
              Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

              Brochure

              Title
              MAPK Pathway Poster ( 750 KB )

              Citations

              Title
            • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision28-February-2012 RFH
              SynonymsNSC23766
              DescriptionA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
              FormLyophilized
              Intert gas (Yes/No) Packaged under inert gas
              CAS number1177865-17-6
              Chemical formulaC₂₄H₃₈Cl₃N₇
              Structure formulaStructure formula
              Purity≥93% by HPLC
              SolubilityH₂O (5 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
              Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
              Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
              Citation
            • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.