538439 RV1088 - CAS 1229606-73-8 - Calbiochem

538439
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₃H₃₄N₆O₄ 1229606-73-8

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38439.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, naphthalene based compound that acts as a narrow spectrum kinase inhibitor and reduces pro-inflammatory cytokine synthesis in LPS-activated primary human macrophages (IC50 = 0.63 and 1.66 nM for TNFα and IL-6), monocytes (IC50 = 0.97, 1.1, and 1.32 nM for TNFα, IL-6, and IL-8), and synovial fibroblasts (5.45 and 1.61 nM for IL-6 and IL-8). Shown to simultaneously inhibit the activity of p38α, p38γ, and Src (c-Src and Hck, and Syk). Also reported to inhibit antigen-induced release of beta-Hex, LTC4, and PGD2 (IC50 = 18, 11, and 21 nM, respectively) in cord blood derived mast cells.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number538439
          Brand Family Calbiochem®
          SynonymsN-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide
          DescriptionRV1088
          References
          ReferencesTo, W. S., et al. 2015. Br. J. Pharmacol. 172, 3805.
          Product Information
          CAS number1229606-73-8
          FormPinkish-brown solid
          Hill FormulaC₃₃H₃₄N₆O₄
          Chemical formulaC₃₃H₃₄N₆O₄
          ReversibleY
          Applications
          Biological Information
          Primary Targetp-38α, p38γ, c-Src, Hck and SyK
          Primary Target IC<sub>50</sub>5.45 nM, 1.61 nM for IL-6, IL-8 inhibition respectively in activated rheumatoid arthritis synovial fibroblasts
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RV1088 - CAS 1229606-73-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          To, W. S., et al. 2015. Br. J. Pharmacol. 172, 3805.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-August-2016 JSW
          SynonymsN-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide
          DescriptionA cell-permeable, naphthalene based compound that acts as a narrow spectrum kinase inhibitor and reduces pro-inflammatory cytokine synthesis in LPS-activated primary human macrophages (IC50 = 0.63 and 1.66 nM for TNFα and IL-6), monocytes (IC50 = 0.97, 1.1, and 1.32 nM for TNFα, IL-6, and IL-8), and synovial fibroblasts (5.45 and 1.61 nM for IL-6 and IL-8). Shown to simultaneously inhibit the activity of p38α, p38γ, and Src (c-Src and Hck, and Syk). Also reported to inhibit antigen-induced release of beta-Hex, LTC4, and PGD2 (IC50 = 18, 11, and 21 nM, respectively) in cord blood derived mast cells.
          FormPinkish-brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1229606-73-8
          Chemical formulaC₃₃H₃₄N₆O₄
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTo, W. S., et al. 2015. Br. J. Pharmacol. 172, 3805.